This is the romantic ship of Audrey Johnson and Dean Winchester. They aren't together but it is hinted that they might become a couple.
When they met.
Dean was a new student and was introduced in history class. After the class, Audrey showed Dean around school. Tiffany beat Dean up at Starbucks after seeing his old notes and texts on his phone. So then Audrey took him to the school nurse.
Dean and Audrey pretty much became friends after that. Dean is starting to like Audrey, not just for his revenge, but is starting to truly like her, more then a friend. (They might become a couple!)